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High intensity statin list trial#

In data released in July, researchers followed more than 320,000 veterans age 75 and older for about seven years. Your physiology doesn’t suddenly change when you turn 75 years of age, says Steven Nissen, M.D., chair of cardiovascular medicine at the Cleveland Clinic. A slew of recent studies have shown that statins may have significant benefits in older age groups. Since, then more than 20 large scale trials and several meta-analysis using pooled data have been published, which have demonstrated the effectiveness of statins in reducing cardiovascular events.Īlso Check: Salmon Roe Cholesterol New Drug Data Show Benefitsīut the picture is becoming clearer. The benefits of statins in decreasing cardiovascular event rates thus became apparent. At the end of the study, total cholesterol was reduced by 25%, LDL-C by 35%, and deaths due to CHD by 42%. A total of 4444 men and women with angina or prior myocardial infarction, and serum cholesterol levels of 5.58.0 mmol/L were randomized to simvastatin or placebo for > 5 years. The Scandinavian Simvastatin Survival Study published in 1994, was the first study that sought to evaluate the effect of statin therapy in the reduction of major coronary events.

High intensity statin list trial#

The lipid-lowering drug cholestyramine was studied in the Coronary Primary Prevention Trial of 1984, and showed a modest reduction in total and LDL-C reduction in coronary events barely reached statistical significance.

your personal and family medical history suggests you’re likely to develop CVD at some point over the next 10 years and lifestyle measures have not reduced this riskįind out more about when statins may be recommended.

you have been diagnosed with a form of CVD.

stroke when the supply of blood to the brain becomes blockedĪ doctor may recommend taking statins if either:.

heart attacks when the supply of blood to the heart is suddenly blocked.

angina chest pain caused by reduced blood flow to the heart muscles.

coronary heart disease when the blood supply to the heart becomes restricted.

It’s the most common cause of death in the UK. ĬVD is a general term that describes a disease of the heart or blood vessels. Having a high level of LDL cholesterol is potentially dangerous, as it can lead to a hardening and narrowing of the arteries and cardiovascular disease. High-sensitivity CRP Show Sources Why Have I Been Offered Statins

If your cardiac risk is intermediate or unclear, but youâre not sure if you want to take medication to treat your high cholesterol, your doctor may suggest one of these heart disease screening tests: If youâre not, you may want to treat high cholesterol with medication. If your cardiac risk score is borderline or intermediate: Your doctor may talk with you about the risks and benefits of cholesterol-lowering drugs, including possible side effects.Īsk yourself if youâre ready to stick with a healthy diet, weight loss, and exercise.

40-75, and your cardiac risk is intermediate.

40-75, and your cardiac risk is borderline.

20-39, with no family history of early heart disease, and your LDL is below 160 mg/dL.

You may not need to treat high cholesterol with medications like statins now if you are:

Heart disease or family history of early heart disease.

Your cardiac risk is based on a combination of these things: Your doctor can use a formula to calculate a score that shows your risk of a heart attack in the next 10 to even 30 years. But if your cardiac risk is high, you may need treatment with medications, too. Everyone with high cholesterol should start with heart-healthy lifestyle changes like diet, exercise, quitting smoking, and weight loss.